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Page 1
How autophagy controls the intestinal epithelial barrier.
Foerster EG, Mukherjee T, Cabral-Fernandes L, Rocha JDB, Girardin SE, Philpott DJ. Foerster EG, et al. Autophagy. 2022 Jan;18(1):86-103. doi: 10.1080/15548627.2021.1909406. Epub 2021 Apr 27. Autophagy. 2022. PMID: 33906557 Free PMC article. Review.
Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-mediated recycling of organelles and protein aggregates, as well as the destruction of intracellular pathogens. Its role in the maintenance of the intestinal epithelium is of particular inter …
Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-mediated recycling of organelles and protein aggregates, a …
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Larabi A, Barnich N, Nguyen HTT. Larabi A, et al. Autophagy. 2020 Jan;16(1):38-51. doi: 10.1080/15548627.2019.1635384. Epub 2019 Jul 9. Autophagy. 2020. PMID: 31286804 Free PMC article. Review.
One of the most significant challenges of inflammatory bowel disease (IBD) research is to understand how alterations in the symbiotic relationship between the genetic composition of the host and the intestinal microbiota, under impact of specific environmental factors, lea …
One of the most significant challenges of inflammatory bowel disease (IBD) research is to understand how alterations in the symbiotic relati …
Metformin: update on mechanisms of action on liver diseases.
Ruan G, Wu F, Shi D, Sun H, Wang F, Xu C. Ruan G, et al. Front Nutr. 2023 Dec 14;10:1327814. doi: 10.3389/fnut.2023.1327814. eCollection 2023. Front Nutr. 2023. PMID: 38192642 Free PMC article. Review.
Metformin regulates caspase-3, eukaryotic initiation factor-2a (eIF2a), and insulin receptor substrate-1 (IRS-1) in palmitate-exposed HepG2 cells, alleviating endoplasmic reticulum (ER) stress. ...The suppression of intestinal farnesoid X receptor (FXR) and the elev …
Metformin regulates caspase-3, eukaryotic initiation factor-2a (eIF2a), and insulin receptor substrate-1 (IRS-1) in palmitate-exposed …
Activation of the EIF2AK4-EIF2A/eIF2alpha-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasive Escherichia coli infection.
Bretin A, Carrière J, Dalmasso G, Bergougnoux A, B'chir W, Maurin AC, Müller S, Seibold F, Barnich N, Bruhat A, Darfeuille-Michaud A, Nguyen HT. Bretin A, et al. Autophagy. 2016 May 3;12(5):770-83. doi: 10.1080/15548627.2016.1156823. Epub 2016 Mar 17. Autophagy. 2016. PMID: 26986695 Free PMC article.
The intestinal mucosa of Crohn disease (CD) patients is abnormally colonized by adherent-invasive E. coli (AIEC). ...We showed that infection of human intestinal epithelial T84 cells with the AIEC reference strain LF82 activated the EIF2AK4-EIF2A-ATF4 pathway …
The intestinal mucosa of Crohn disease (CD) patients is abnormally colonized by adherent-invasive E. coli (AIEC). ...We showed that i …
miR-195 promotes LPS-mediated intestinal epithelial cell apoptosis via targeting SIRT1/eIF2a.
Yuan T, Zhang L, Yao S, Deng SY, Liu JQ. Yuan T, et al. Int J Mol Med. 2020 Feb;45(2):510-518. doi: 10.3892/ijmm.2019.4431. Epub 2019 Dec 18. Int J Mol Med. 2020. PMID: 31894250 Free PMC article.
The present study investigated the effect of miR-195 on apoptosis in sepsis and investigated the underlying mechanism. The level of miR-195 was measured in human intestinal epithelial cells following exposure to lipopolysaccharide (LPS). ...
The present study investigated the effect of miR-195 on apoptosis in sepsis and investigated the underlying mechanism. The level of miR-195 …
Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation.
Roy S, Esmaeilniakooshkghazi A, Patnaik S, Wang Y, George SP, Ahrorov A, Hou JK, Herron AJ, Sesaki H, Khurana S. Roy S, et al. Gastroenterology. 2018 Apr;154(5):1405-1420.e2. doi: 10.1053/j.gastro.2017.12.016. Epub 2017 Dec 21. Gastroenterology. 2018. PMID: 29274870 Free PMC article.
Actin is modified during stress and EIF2A is dephosphorylated to restore homeostasis. It is not clear how actin affects EIF2A signaling. ...We performed immunohistochemical analyses of distal ileum tissues from 6-8 patients with Crohn's disease (CD) and 6-8 individu …
Actin is modified during stress and EIF2A is dephosphorylated to restore homeostasis. It is not clear how actin affects EIF2A …
Colostrum oxytocin modulates cellular stress response, inflammation, and autophagy markers in newborn rat gut villi.
Klein BY, Tamir H, Ludwig RJ, Glickstein SB, Welch MG, Anwar M. Klein BY, et al. Biochem Biophys Res Commun. 2017 May 20;487(1):47-53. doi: 10.1016/j.bbrc.2017.04.011. Epub 2017 Apr 5. Biochem Biophys Res Commun. 2017. PMID: 28389244
Here, we explored whether colostrum-OT attenuates stress in newborn villi primed and unprimed by colostrum by measuring levels of stress markers including BiP (an ER chaperone), eIF2a (translation initiation factor), and pPKR (eIF2a kinase). We also measured two inf …
Here, we explored whether colostrum-OT attenuates stress in newborn villi primed and unprimed by colostrum by measuring levels of stress mar …
Oxytocin modulates markers of the unfolded protein response in Caco2BB gut cells.
Klein BY, Tamir H, Hirschberg DL, Glickstein SB, Ludwig RJ, Welch MG. Klein BY, et al. Cell Stress Chaperones. 2014 Jul;19(4):465-77. doi: 10.1007/s12192-013-0473-4. Epub 2013 Nov 6. Cell Stress Chaperones. 2014. PMID: 24198165 Free PMC article.
Importantly, high OT increased phosphorylation of eukaryotic translation initiation factor 2a (eIF2a) phospho-Ser51, which inhibits eIF2a. High OT also increased protein kinase RNA-like endoplasmic reticulum kinase phosphorylation, a sensor of ER stress and a kinase …
Importantly, high OT increased phosphorylation of eukaryotic translation initiation factor 2a (eIF2a) phospho-Ser51, which inhibits …
Oxytocin opposes effects of bacterial endotoxin on ER-stress signaling in Caco2BB gut cells.
Klein BY, Tamir H, Hirschberg DL, Ludwig RJ, Glickstein SB, Myers MM, Welch MG. Klein BY, et al. Biochim Biophys Acta. 2016 Feb;1860(2):402-11. doi: 10.1016/j.bbagen.2015.10.025. Epub 2015 Oct 28. Biochim Biophys Acta. 2016. PMID: 26520666
OT selectively activates dsRNA-activated kinase (PKR), X-box binding protein 1 (XBP1), immunoglobulin binding protein (BiP), A20 (TNFalpha-induced protein 3) and inositol requiring enzyme 1a (IRE1a). OT inactivates eukaryotic translation initiation factor 2a (eIF2a) withou …
OT selectively activates dsRNA-activated kinase (PKR), X-box binding protein 1 (XBP1), immunoglobulin binding protein (BiP), A20 (TNFalpha-i …
Involvement of endoplasmic reticulum stress in inflammatory bowel disease: a different implication for colonic and ileal disease?
Bogaert S, De Vos M, Olievier K, Peeters H, Elewaut D, Lambrecht B, Pouliot P, Laukens D. Bogaert S, et al. PLoS One. 2011;6(10):e25589. doi: 10.1371/journal.pone.0025589. Epub 2011 Oct 18. PLoS One. 2011. PMID: 22028783 Free PMC article.
Colonic IBD was associated with increased phosphorylation of EIF2A suggesting the activation of the PERK branch, but subsequent induction of GADD34 was not observed. ...CONCLUSIONS/SIGNIFICANCE: Activation of the three UPR-related arms is seen in colonic IBD-associated inf …
Colonic IBD was associated with increased phosphorylation of EIF2A suggesting the activation of the PERK branch, but subsequent induc …